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Durham e-Theses
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Development of Coherent Raman
Scattering Microscopy for Monitoring
Drug Delivery

PICKUP-GERLAUGH, ADAM,JOHN (2017) Development of Coherent Raman
Scattering Microscopy for Monitoring
Drug Delivery.
Doctoral thesis, Durham University.



Topical pharmaceuticals are a vitally important part of modern medicine. Currently,
characterising the dermatopharmacokinetics of these drugs is very difficult, and not
possible in either real-time, or with a high level of accuracy. This thesis applies three
coherent Raman scattering microscopy techniques to the challenge of video-rate
monitoring of a porcine skin model undergoing penetration by two different, widely used,
pharmaceuticals. It was found that the data taken during these time-course experiments
could be used in conjunction with a Beer-Lambert expression, and Fick’s second law, to
extract valuable permeation data – namely the skin-solute partition coefficient, and
diffusion coefficient – of these pharmaceuticals.

Item Type:Thesis (Doctoral)
Award:Doctor of Philosophy
Faculty and Department:Faculty of Science > Physics, Department of
Thesis Date:2017
Copyright:Copyright of this thesis is held by the author
Deposited On:04 Dec 2017 13:26

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