Cyclotron production of short-lived radionuclides and labelled compounds for use in biomedical research and clinical diagnosis

Abstract

The works submitted in this thesis cover the development of methods for the production in a cyclotron of a variety of radionuclides and their incorporation in radio-labelled compounds for use in biomedical research. In addition, papers are included which describe biomedical applications of such radio-tracers. My co-authorship of these publications reflects my interest in the design and execution of experiments in the realm of interdisciplinary research. The original contributions to science embodied in the publications submitted include examples of novel radiochemistry applied in the areas of cyclotron production of short half-life radionuclides and their radiochemical purification. In many cases the use of these radionuclides in biomedical research has added new information to the body of medical scientific Toiowledge. Novel radiolabelling strategies using very short half-life radionuclides are included. These have necessitated the development of rapid radio-organic syntheses, several of which have been achieved using automated microchemical engineering process plants of my design. I have also developed novel systems for the administration of radionuclies and radio-labelled compounds of pharmaceutical quality, widely acknowledged to be "World Firsts." My invention of the (^81)Kr(^m) radionuclide generator resulted in publications covering a wide range of medical applications. These are included with the thesis. The device is now produced in many countries around the world for use both in routine clinical diagnosis and in research, particularly in lung disease. More recently, I have created an automated bedside infuser of H(_2)(^15)O, which has revolutionised measurements of regional cerebral blood flow using the technique of Positron Emission Tomography for in vivo regional mapping of brain activity.