Microreactors and other technologies for direct fluorination

Abstract

Quinoline/ 2H-chromen-2-one and derivatives thereof, have been found to undergo electrophilic substitution by elemental fluorine in concentrated sulfuric acid as reaction medium. This work has enabled a series of fluorinated derivatives to be prepared. Furthermore, several direct fluorination microreactors have been designed and subsequently evaluated regarding scale-out, and thus the fluorination of a number of organic compounds was achieved using microreactor technology.