We use cookies to ensure that we give you the best experience on our website. By continuing to browse this repository, you give consent for essential cookies to be used. You can read more about our Privacy and Cookie Policy.

Durham e-Theses
You are in:

Polyfunctional heteroaromatic fused ring systems

Slater, Rachel (2005) Polyfunctional heteroaromatic fused ring systems. Doctoral thesis, Durham University.

[img]Microsoft Word (Crystal structure data tables) - Supplemental Material


Many current therapeutic agents are based on a core structure consisting of a fused ring heteroaromatic polycyclic system. Methodology for the synthesis of a range of these structurally diverse heteroaromatic derivatives is therefore highly desirable and short, high yielding, regioselective and flexible routes to such systems is very important. Our methodology utilises nucleophilic substitution reactions between pentafluoropyridine (PFP) and its derivatives, and various binucleophiles, e.g. The methodology has also been extended to 4-substituted tetrafluoropyridine derivativesand different binucleophiles, resulting in the successful synthesis of, among others, the system shown below. These fused systems are also reactive to further nucleophilic substitutions.

Item Type:Thesis (Doctoral)
Award:Doctor of Philosophy
Thesis Date:2005
Copyright:Copyright of this thesis is held by the author
Deposited On:09 Sep 2011 09:54

Social bookmarking: del.icio.usConnoteaBibSonomyCiteULikeFacebookTwitter