COOPER, DANIEL,ANDREW (2019) Synthesis of aryl-CHFCF3 systems. Masters thesis, Durham University.
|Full text not available from this repository.|
Author-imposed embargo until 06 May 2021.
The fluorine-containing functional group Ar-CFHCF3 is potentially useful within the pharmaceutical, agrochemical and polymer industries if synthetic methodology is available for the synthesis of these systems. Here, a new general synthetic pathway for the synthesis of 1-aryl-1,2,2,2-tetrafluoroethanes starting from either benzaldehyde or 3-pyridinecarboxaldehyde derivatives is presented.
Reactions of aldehydes with CF3SiMe3 and a catalyst of TBAF (tetrabutylammonium fluoride) and then DAST (diethylaminosuphur trifluoride) were generally very efficient for a range of substrates bearing electron donating/ withdrawing substituents on the aromatic ring.
|Item Type:||Thesis (Masters)|
|Award:||Master of Science|
|Faculty and Department:||Faculty of Science > Chemistry, Department of|
|Copyright:||Copyright of this thesis is held by the author|
|Deposited On:||09 May 2019 14:01|