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Durham e-Theses
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Synthesis of aryl-CHFCF3 systems.

COOPER, DANIEL,ANDREW (2019) Synthesis of aryl-CHFCF3 systems. Masters thesis, Durham University.

Full text not available from this repository.
Author-imposed embargo until 06 May 2021.

Abstract

The fluorine-containing functional group Ar-CFHCF3 is potentially useful within the pharmaceutical, agrochemical and polymer industries if synthetic methodology is available for the synthesis of these systems. Here, a new general synthetic pathway for the synthesis of 1-aryl-1,2,2,2-tetrafluoroethanes starting from either benzaldehyde or 3-pyridinecarboxaldehyde derivatives is presented.

Reactions of aldehydes with CF3SiMe3 and a catalyst of TBAF (tetrabutylammonium fluoride) and then DAST (diethylaminosuphur trifluoride) were generally very efficient for a range of substrates bearing electron donating/ withdrawing substituents on the aromatic ring.

Item Type:Thesis (Masters)
Award:Master of Science
Keywords:Organofluorine chemistry
Faculty and Department:Faculty of Science > Chemistry, Department of
Thesis Date:2019
Copyright:Copyright of this thesis is held by the author
Deposited On:09 May 2019 14:01

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